After getting your fill of historical tours and neoclassical monuments, head over to the Scheunenviertel area of Mitte, a very charming, more residential area, where you'll find independent art galleries, fashionable boutiques, and plenty of sidewalk cafe culture.
More shopping and restaurants can be found in Hackescher Markt, an attractive corner of Mitte that is home to Hackesche Höfe, with its abundance of cafes and shops as well as cinema and theater. After hours, head to the street Oranienburger Straße for rows of hopping nightclubs and bars.